Fourier Transform Infrared Spectroscopy (FTIR)
We have extensive experience in using FTIR for investigative skin research to provide non-invasive structural information on the skin barrier in vivo.
What is FTIR?
It is a powerful tool used to analyse the chemical composition of surfaces including the skin. Adult, child and infant cohorts can be rapidly screened using this technique. Here at SDR we utilise a portable spectrometer device that is ideal for use in busy clinical environments where laboratory space is not an option.
How does it work?
FTIR is a form of spectroscopy. Absorbance of light in the mid infrared region provides a molecular fingerprint of the stratum corneum. This relates to its structural lipid composition, water content and the level of Natural Moisturising Factors (NMF).
FTIR for Atopic Dermatitis (AD)
We use FTIR to assess the defective skin barrier in AD. In combination with tape stripping the SC can be comprehensively studied across its full depth.
FTIR for the instantaneous quantification of Natural Moisturising Factors (NMF)
No longer do we have to wait days for laboratory NMF analysis by HPLC. Here at SDR we utilize FTIR modelling to instantaneously quantify NMF levels in vivo to inform on the acquired and inherited skin barrier defect.
FTIR to monitor treatment of the skin barrier (RESTORE Trial)
The benefit of topical treatments such as emollients can also be studied using FTIR. Here we demonstrate the superior effect of CeraVe (blue) compared to the widely prescribed Zerobase cream (red) on lipid structure and hydration following 28 days treatment.
