Poster Gallery
2024
Dupilumab Treatment Restores Skin Barrier in Children Aged 6 to 11 Years With Moderate-to-Severe Atopic Dermatitis
Michael J. Cork, Peck Y. Ong, Simon G. Danby, Marco Ramirez-Gama, Shannon Garcia, Patricia A. Taylor, Robert A. Byers, Stephen J. Matcher, Oludolapo S. Katibi, Kirsty Brown, Paul V. Andrew, Abigail Pinnock, Anna Poyner, Laura Johnson, Stuart Gormley, Joseph Zahn, Gabriel Bologna, Amy Praestgaard, Annie Zhang, Donald Y.M. Leung
Presented at the 33rd European Academy of Dermatology and Venereology Congress (EADV); Amsterdam, Netherlands; September 25–28, 2024
Leveraging Optical Biomarkers for Sub-clinical Atopic Dermatitis Severity Monitoring
Robert Byers, P. Andrew, S. Sahib, O. Katibi, K. Brown, A. Poyner, J. Chittock, S. Williams, L. Johnson, F. Wright, S. Matcher, O. Sørensen, M. Cork, S. Danby
Presented at the 2024 NIHR BRC showcase; Sheffield, UK; May 10, 2024
Dupilumab Provides Sustained Normalization of Skin Barrier Function in Children With Moderate-to-Severe Atopic Dermatitis
Michael J. Cork, Evgeny Berdyshev, Elena Goleva, Simon G. Danby, Irina Bronova, Joseph Zahn, Inoncent Agueusop, Zhanyun Hu, Peck Ong, Annie Zhang, Donald Y.M. Leung
Presented at the 2024 Annual Meeting of the American Academy of Dermatology (AAD24); San Diego, CA, USA; March 8–12, 2024
Dupilumab Treatment Provides Sustained Improvement in Skin Barrier Function, Clinical Outcomes, and Patient-Reported Outcome in Patients Aged 6 to 11 Years With Moderate-to-Severe Atopic Dermatitis
Michael J. Cork, Peck Ong, Simon G. Danby, Marco Ramirez-Gama, Shannon Garcia, Patricia Taylor, Joseph Zahn, Gabriel Bologna, Annie Zhang, Donald Y.M. Leung
Presented at the 2024 Annual Meeting of the American Academy of Dermatology (AAD24); San Diego, CA, USA; March 8–12, 2024
2023
Dupilumab Treatment Normalizes Skin Barrier Function and Improves Patient-Reported Outcomes in Patients Aged 6 to 11 Years With Moderate-to-Severe Atopic Dermatitis
Michael J. Cork, Donald Y.M. Leung, Peck Ong, Simon G. Danby, Marco Ramirez-Gama, Shannon Garcia, Patricia Taylor, Joseph Zahn, Amy Praestgaard, Gabriel Bologna, Annie Zhang
Presented at the 5th Inflammatory Skin Disease Summit (ISDS23); Vienna, Austria; November 15–18, 2023
Long-Term Dupilumab Treatment Is Not Associated With an Increased Overall Risk of Infections in Patients Aged 6 Months to 5 Years With Moderate-to-Severe Atopic Dermatitis in an Open-Label Extension Study
Amy S. Paller, Michele Ramien, Michael J. Cork, Eric L. Simpson, Lara Wine Lee, Lawrence F. Eichenfield, Anna Coleman, Guy Gherardi, Zhen Chen, Annie Zhang, Sonya L. Cyr
Presented at the 11th Pediatric Dermatology Research Alliance (PeDRA) Annual Conference; Atlanta, GA, USA; November 9–11, 2023
Dupilumab Treatment Normalizes Skin Barrier Function and Improves Patient-Reported Outcomes in Children Aged 6 to 11 Years With Moderate-to-Severe Atopic Dermatitis
Michael J. Cork, Donald Y.M. Leung, Peck Ong, Simon G. Danby, Marco Ramirez-Gama, Shannon Garcia, Patricia Taylor, Rob Byers, Stephen Matcher, Oludolapo Sherifat Katibi, Joseph Zahn, Amy Praestgaard, Gabriel Bologna, Annie Zhang
Presented at the European Academy of Dermatology and Venereology (EADV 2023); Berlin, Germany; October 11-14, 2023
Efficacy and Safety of Dupilumab Treatment up to 1 Year in Infants and Preschool Children With Moderate-to-Severe Atopic Dermatitis
Michael J. Cork, Amy S. Paller, Elaine C. Siegfried, Jing Xiao, Randy Prescilla, Ariane Dubost-Brama, Ashish Bansal
Presented at the 13th Georg RAJKA Symposium of the International Society of Atopic Dermatitis (ISAD); Gdańsk, Poland; August 31 – September 2, 2023
Acidification of the skin surface, coupled with the delivery of key lipids, using a novel zinc-lactobionate preparation improves skin barrier function in atopic dermatitis patients
S Danby, P Andrew, A Poyner, A Pinnock, K Brown, J Chittock, M Cork
Presented at the 25th World Congress of Dermatology; Suntec City, Singapore; July 3-8, 2023
Recommendation and use of skin care products on infants among health workers in Nigeria
O Katibi, A Ogunbiyi, M Cork, S Danby
Presented at the 25th World Congress of Dermatology; Suntec City, Singapore; July 3-8, 2023
A preliminary investigation of the effects of regular emollient use on cutaneous allergen reaction
O Katibi, P Andrew, A Poyner, A Pinnock, K Brown, R Byers, M Cork, S Danby
Presented at the 25th World Congress of Dermatology; Suntec City, Singapore; July 3-8, 2023
A Head-to-Head Comparison of Two Topical Anti-inflammatory Treatments, Crisaborole and Betamethasone Valerate, Reveals Marked Differences in Their Effects on the Microstructure of the Skin
Simon G. Danby, Stephen Matcher, Robert Byers, Rosie Taylor, Sura Sahib, Paul Andrew, Kirsty Brown, Linda Kay, Carl Wright, Abi Pinnock, John Chittock, Mengqiu Duan, Amy Cha, Roni Adiri, Chuanbo Zang, John Werth and Michael J. Cork
Presented at the 25th World Congress of Dermatology; Suntec City, Singapore; July 3-8, 2023
Dupilumab Treatment Restores Skin Barrier Function in Lesional and Non-Lesional Skin of Patients With Atopic Dermatitis and Improves Patient-Reported Outcomes
Michael J. Cork, Robert Bissonnette, Marco Ramirez-Gama, Patricia Taylor, Amy Praestgaard, Noah A. Levit, Ana B. Rossi, Annie Zhang
Presented at the 103rd Annual Meeting of the British Association of Dermatologists (BAD 2023); Liverpool, UK; June 27–29, 2023
Efficacy and safety of dupilumab treatment up to 1 year in infants and preschool children with moderate-to-severe atopic dermatitis
Michael J. Cork, Amy S. Paller, Elaine C. Siegfried, Jing Xiao, Randy Prescilla, Ariane Dubost-Brama, Ashish Bansal
Presented at the 22nd Congress of the European Society for Pediatric Dermatology (ESPD); Málaga, Spain; May 4-6, 2023
Dupilumab Treatment Normalises Skin Barrier Function in Children Aged 6 to 11 Years With Moderate-to-Severe Atopic Dermatitis
Michael J. Cork, Donald Y.M. Leung, Peck Ong, Simon G. Danby, Marco Ramirez-Gama, Shannon Garcia, Patricia Taylor, Joseph Zahn, Amy Praestgaard, Gabriel Bologna, Annie Zhang
Presented at the 22nd Congress of the European Society for Pediatric Dermatology (ESPD); Málaga, Spain; May 4-6, 2023
Clinically meaningful responses to dupilumab among children aged 6 months to 5 years with moderate-to-severe atopic dermatitis
Michael J. Cork, Benjamin Lockshin, Andreas Pinter, Zhen Chen, Randy Prescilla, Brad Shumel
Presented at the 22nd Congress of the European Society for Pediatric Dermatology (ESPD); Málaga, Spain; May 4-6, 2023
The potential application of Polarisation Sensitive - Optical Coherence Tomography (PS-OCT) in the safety assessment of non-steroidal topical creams for atopic dermatitis (AD) treatment
Meng Q. Duan, Robert A. Byers, Simon G. Danby, Amy Cha, Roni Adiri, Chuanbo Zang, John Werth, Rosie N. Taylor, Michael J. Cork, Stephen J. Matcher
Presented at the SPIE Photonics West 2023 Conference; San Francisco, USA; January 28, 2023
2022
A randomized controlled phase 2 trial comparing the effects of crisaborole 2% ointment to betamethasone valerate 0.1% cream on skin structure in participants with atopic dermatitis
Simon G. Danby, Stephen Matcher, Robert Byers, Rosie Taylor, Sura Sahib, Paul Andrew, Kirsty Brown, Linda Kay, Carl Wright, Abi Pinnock, John Chittock, Mengqiu Duan, Amy Cha, Roni Adiri, Chuanbo Zang, John Werth and Michael J. Cork
Presented at the International Society of Atopic Dermatitis (ISAD) Hybrid Congress; Montréal, Canada; October 7-19, 2022
Health-Related Quality-of-Life Improvements With Abrocitinib by Clinical Response Status in Patients With Moderate-to-Severe Atopic Dermatitis
Michael J. Cork, Dirk Jan Hijnen, Claire Feeney, Pinaki Biswas, Fan Zhang, Daniela E. Myers, Marco DiBonaventura
Presented at the International Society of Atopic Dermatitis (ISAD) Hybrid Congress; Montréal, Canada; October 7-19, 2022
Long-Term Efficacy of Abrocitinib After Initial Successful Treatment in Patients With Atopic Dermatitis
Michael J. Cork, Kim A. Papp, Mette Deleuran, Andrew E. Pink, Kristian Reich, Pinaki Biswas, Gary Chan, Claire Feeney, Wing Sin Chiu, Rowena M. Randall
Presented at the Maui Derm NP+PA; Nashville, USA; September 18-21, 2022
Dupilumab Treatment Is Not Associated With an Increased Overall Risk of Infections in Patients Aged 6 Months to 5 Years With Moderate-to-Severe Atopic Dermatitis
Michael J. Cork, Elaine C. Siegfried, Peter D. Arkwright, Andreas Wollenberg, Lawrence F. Eichenfield, Michele Ramien, Faisal A. Khokhar, Maria Vass, Zhen Chen, Annie Zhang, Sonya L. Cyr
Presented at the 31st Congress of the European Academy of Dermatology and Venereology (EADV 2022); Milan, Italy; September 7–10, 2022
Dupilumab Provides Long-Term Improvement in Pruritus in Children With Severe Atopic Dermatitis, and Adolescents and Adults With Moderate-to-Severe Atopic Dermatitis
Michael J. Cork, Gil Yosipovitch, Jonathan I. Silverberg, Amy Praestgaard, Haixin Zhang, Zhixiao Wang, Ana B. Rossi
Presented at the 102nd Annual Meeting of the British Association of Dermatologists (BAD); Glasgow, UK; July 2022
Optimization of Common Hand Cleansers for protection from Viral spread and occupational hand Dermatoses
Winder NJ, Stark K, Cork MJ, Danby SG, Muthana M
Presented at the American Academy of Dermatology (AAD); Boston, USA; March 2022
The Use of Distraction Techniques for Painful Research Procedures in Children
Lynne Hardy-Azevedo & Alison Hyde
Sheffield Children’s Clinical Research Facility
2021
Lowering skin surface pH with a topical zinc lactobionate preparation containing physiologic lipids improves skin barrier structure and function in adults with atopic dermatitis
THE BARRIER STUDY 2
Simon G Danby, Paul V Andrew, Abigail Pinnock, Linda Kay, John Chittock, Michael J Cork
Presented at the 11th Georg Rajka International Symposium on Atopic Dermatitis (ISAD), Seoul, South Korea 2021
52-Week Laboratory Safety Findings From an Open-Label Extension (OLE) Study of Dupilumab in Adolescent Patients With Atopic Dermatitis
LIBERTY AD PED-OLE
Michael J. Cork, Benjamin Lockshin, Andrew Blauvelt, Zhen Chen, Faisal A. Khokhar, Ashish Bansal, Randy Prescilla
Presented at the American Academy of Dermatology (AAD), San Francisco 2021
Long-Term Efficacy and Safety Data of Dupilumab in a Phase 3, Open-Label Extension Trial (LIBERTY AD PED-OLE) in Patients Aged ≥ 6 to < 12 Years With Uncontrolled, Moderate-to-Severe Atopic Dermatitis
Michael J. Cork, Diamant Thaçi, Lawrence Eichenfield, Peter D. Arkwright, Zhen Chen, Dimittri Delevry, John T. O’Malley, Ashish Bansal
Presented at the American Academy of Dermatology (AAD), San Francisco 2021
Laboratory Safety of Dupilumab in Adolescent Patients With Atopic Dermatitis: 52-Week Laboratory Safety Findings From an Open-Label Study (LIBERTY AD PED-OLE)
Michael J. Cork, Benjamin Lockshin, Andrew Blauvelt, Zhen Chen, Randy Prescilla, Ashish Bansal
Presented at the Innovations in Dermatology Virtual Spring Conference, 2021
2020
AN INVESTIGATION OF THE SKIN BARRIER RESTORING EFFECTS OF A CREAM CONTAINING CERAMIDES IN A MULTI VESICULAR EMULSION IN PEOPLE WITH DRY, ECZEMA-PRONE, SKIN
THE RESTORE STUDY PHASE 2
Danby SG, Andrew PV, Kay LJ, Pinnock A, Chittock J, Brown K, Cork MJ
Presented at the American Academy of Dermatology (AAD) virtual meeting, San Francisco 2020
Dupilumab Improves Signs and Symptoms in Adult and Adolescent Patients With Erythrodermic Atopic Dermatitis – A Pooled Subgroup Analysis
Michael J. Cork, Benjamin Lockshin, Marie-Anne C.J. Morren, Takafumi Etoh, Zhen Chen, Ana B. Rossi, Yufang Lu, Ashish Bansal, Arsalan Shabbir
Presented at Journées Dermatologiques de Paris (JDP), 2020
Laboratory Safety of Dupilumab in Adolescent Patients With Atopic Dermatitis: 52-Week Laboratory Safety Findings From an Open-Label Study (LIBERTY AD PED-OLE)
Michael J. Cork, Benjamin Lockshin, Andrew Blauvelt, Zhen Chen, Faisal A. Khokhar, Randy Prescilla, Paola Mina-Osorio, Ashish Bansal
Presented at the European Academy of Dermatology and Venereology (EADV) virtual meeting, 2020
2019
AN INVESTIGATION OF THE SKIN BARRIER RESTORING EFFECTS OF A CREAM CONTAINING CERAMIDES IN A MULTI VESICULAR EMULSION IN PEOPLE WITH DRY, ECZEMA-PRONE, SKIN
THE RESTORE STUDY
Danby SG, Andrew PV, Kay LJ, Pinnock A, Chittock J, Brown K, Cork MJ
Presented at the British Association of Dermatologists (BAD) meeting, Liverpool 2019
2018
Quantification of Natural Moisturising Factors at the skin surface using a portable infrared spectrometer device: a pilot calibration model
John Chittock, Kirsty Brown, Michael J. Cork and Simon G. Danby
Presented at the 10th Georg Rajka International Symposium on Atopic Dermatitis (ISAD), Utrecht, Netherlands 2018
2017
Characterising the microcirculation of atopic dermatitis using angiographic optical coherence tomography
R. Byers, R. Maiti, S. Danby, E. Pang, B. Mitchell, M. Cork and S. Matcher
Presented at the 67th Annual meeting of the British Microcirculation Society (BMS), Birmingham 2017
Also presented as a talk at Photonics West, San Francisco 2017
2016
The neonate epidermal barrier: development of superficial chymotrypsin-like protease activity and natural moisturising factors
John Chittock, Alison Cooke, Tina Lavender, Kirsty Brown, Andrew Wigley, Suresh Victor, Michael J. Cork and Simon G. Danby
Presented at the 9th Georg Rajka International Symposium on Atopic Dermatitis (ISAD), Sao Paulo, Brazil 2016
Characterisation of the skin barrier defect in atopic dermatitis using in vivo ATR-FTIR molecular spectroscopy
Simon G. Danby, Helen Wan, John Chittock, Kirsty Brown, Andrew Wigley, Michael J. Cork
Presented at the 9th Georg Rajka International Symposium on Atopic Dermatitis (ISAD), Sao Paulo, Brazil 2016
The effect of a complex emollient cream containing 5% urea, ceramide 3 and lactic acid, compared to a simple emollient, on the skin barrier in older people with dry skin
S. G. Danby, K. Brown, T. Higgs-Bayliss, J. Chittock, M. J. Cork
Presented at the British Association of Dermatologists (BAD) meeting, Glasgow 2016
Abnormal corneodesmosome distribution in atopic dermatitis and soap-induced xerosis
A. Wigley, K. Brown, H. Wan, M. J. Cork, S. G. Danby
Presented at the 15th Skin Forum annual meeting, London 2016
2015
A functional mechanistic study to investigate the effect of topical anti-inflammatory therapy on the epidermal barrier: implications for the treatment of atopic dermatitis
John Chittock, Kirsty Brown, Michael J. Cork, Stephen J. Matcher, Zenghai Lu, Joseph Boadi and Simon G. Danby
Presented at the World Congress of Dermatology (WCD), Vancouver 2015
Comparing the effect of tacrolimus (0.1%) ointment and betamethasone valerate (0.1%) cream on the epidermal barrier: a twice-weekly maintenance dose
John Chittock, Kirsty Brown, Michael J. Cork and Simon G. Danby
Presented at the World Congress of Dermatology (WCD), Vancouver 2015
Soap-induced damage to the stratum corneum arises as a result of elevated proteolytic degradation of corneodesmosomes
S. G. Danby, A. Wigley, N. Tierney, K. Martin, G. Stamatas, M. J. Cork
Presented at the World Congress of Dermatology (WCD), Vancouver 2015
The effect of a humectant emollient cream containing 5% urea compared to a non-humectant emollient on the skin barrier in older people with dry skin
S. G. Danby, K. Brown, T. Higgs-Bayliss, J. Chittock, M. J. Cork
Presented at the World Congress of Dermatology (WCD), Vancouver 2015
2014
Non-invasive assessment of the lipid structure and water holding properties of the stratum corneum in vivo by ATR-FTIR using a fibre optic probe in patients with atopic dermatitis and healthy controls
T. Higgs-Bayliss, K. Brown, J. Chittock, M. J. Cork, S. G. Danby
Presented at the 8th Georg Rajka International Symposium on Atopic Dermatitis (ISAD), Nottingham 2014
2013
The effect of an emollient cream containing 5% urea on the biophysical properties of aged skin
K. Brown, T. Higgs-Bayliss, J. Chittock, M.J. Cork, and S.G. Danby
Presented at the International Investigative Dermatology (IID) meeting, Edinburgh 2013
The effect of topical anti-inflammatories on the skin barrier: Implications for the long-term treatment of AD
J. Chittock, K. Brown, M. J. Cork, S. J. Matcher, Zenghai Lu, J. Boadi and S. Danby
Presented at the International Investigative Dermatology (IID) meeting, Edinburgh 2013
Chymotrypsin-like protease activity in the stratum corneum is increased in atopic dermatitis and upon washing with soap
S. Danby, M. J. Cork, J. Chittock, K. M. Martin and N. K. Tierney
Presented at the International Investigative Dermatology (IID) meeting, Edinburgh 2013
2011
A case of life-threatening infections due to preservative absence in a topical cream and audit demonstrating magnitude of the problem
Amani Sultan, Julie Carr, Simon Danby, Michael Akram, Andrew Messenger, Patricia Fenton, Manar Moustafa, Michael J. Cork
Presented at the International Conference of Midwives (ICM) meeting, Durban 2011
2008
Therapeutic implications of the differential effects of topical corticosteroids and calcineurin inhibitors on the skin barrier
Cork MJ, Varghese J, Sultan A, Guy R, Lane M, Al Enezi T, Hadgraft J, Ward S
Presented at the 5th Georg Rajka International Symposium on Atopic Dermatitis (ISAD), Kyoto 2008
Skin Protease Inhibitors: A New Treatment for Atopic Dermatitis
S. Danby, M. Moustafa, A.L. MacGowan, S.J. Ward and M.J. Cork
Presented at the 5th Georg Rajka International Symposium on Atopic Dermatitis (ISAD), Kyoto 2008
Contamination of emollient creams and ointments with staphylococcus aureus – in children with atopic eczema
Carr J, Akram M, Sultan A, Hunter L, Moustafa M, Messenger A, Fenton P, Cork MJ
Presented at the 5th Georg Rajka International Symposium on Atopic Dermatitis (ISAD), Kyoto 2008